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KMID : 0357920020360020100
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Korean Journal of Pathology
2002 Volume.36 No. 2 p.100 ~ p.105
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Alleic Loss at the BRCA1 and BRCA2 Loci iin Sporadic Breast Carcinoma Using Paraffin Embedded Tissue
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Park Ji-Young
Lee Myung-Hoon
Kim Dong-Ja
Park Tae-In
Lee Young-Ha
Kim Jung-Wan
Sohn Yoon-Kyung
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Abstract
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Background: Germline mutations in the breast cancer-associated genes BRCA1 and BRCA2 confer susceptibility and a lifetime risk of breast cancer. Several morphological and clinical features have been attributed to hereditary tumors. However, in sporadic breast cancer, the interrelationshp between the loss of heterozygosity (LOH) of these loci and clinical features remains to be fuly elucidated.
Methods: Microdissected paraffin-embedded tissue blocks of 48 cases of surgicall resected breast carcinoma were investigated to identify the LOH of BRCA1 and BRCA2 using microsatellite markers.
Results: Of 48 cases, 22(45.9%) exhibited LOH at BRCA1 locus while in 29 out of 48 (60.4%) cases LOH was observed for the BRCA2 region. There was no signicificant correlation between LOH was BECA1/2 and the patients’s age, tumor size, histologic grade or lymph node metastasis. When comparing the frequency of LOH with the expression of several prognostic factors, such as p53, c-erb B2 protein, estrogen and progesterone receptor using immunohistochmeical stain, there was only correlatio with LOH at BRCA2 and the progesterone receptor.
Conclusions: Our results suggest that allelic deletion play a role to the development of sporadic breast cancers.
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KEYWORD
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Mammary Neoplasms, Loss of Heterozygosity-Genes, BRCA1-Genes, BRCA2
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